Schooling fish, swarms of starlings, plodding wildebeest, and musicians all display impressive synchronization. To what extent do they use acoustic cues to achieve these feats? Could the acoustic cues used in movement synchronization be relevant to the treatment of movement disorders such as Parkinson's disease in humans? In this article, we build on the emerging view in evolutionary biology that the ability to synchronize movement evolved long before language, in part due to acoustic advantages. We use this insight to explore (...) potential mechanisms that explain why music therapy has beneficial effects for PD patients. We hypothesize that rhythmic auditory cues, particularly music, can stimulate neuronal and behavioral processes that ease the symptoms and potentially the causes of PD because the neural circuits used in auditory entrainment at individual and group levels are associated with dopamine production. We summarize current treatment of PD and outline how new insights from an evolutionary perspective could improve understanding and eventual treatment of movement disorders in humans. (shrink)

We argue that artificial networks are explainable and offer a novel theory of interpretability. Two sets of conceptual questions are prominent in theoretical engagements with artificial neural networks, especially in the context of medical artificial intelligence: Are networks explainable, and if so, what does it mean to explain the output of a network? And what does it mean for a network to be interpretable? We argue that accounts of “explanation” tailored specifically to neural networks have ineffectively reinvented the wheel. In (...) response to, we show how four familiar accounts of explanation apply to neural networks as they would to any scientific phenomenon. We diagnose the confusion about explaining neural networks within the machine learning literature as an equivocation on “explainability,” “understandability” and “interpretability.” To remedy this, we distinguish between these notions, and answer by offering a theory and typology of interpretation in machine learning. Interpretation is something one does to an explanation with the aim of producing another, more understandable, explanation. As with explanation, there are various concepts and methods involved in interpretation: Total or Partial, Global or Local, and Approximative or Isomorphic. Our account of “interpretability” is consistent with uses in the machine learning literature, in keeping with the philosophy of explanation and understanding, and pays special attention to medical artificial intelligence systems. (shrink)

We claim that if a complete philosophy of evidence-based practice is intended, then attention to the nature of causation in health science is necessary. We identify how health science currently conceptualises causation by the way it prioritises some research methods over others. We then show how the current understanding of what causation is serves to constrain scientific progress. An alternative account of causation is offered. This is one of dispositionalism. We claim that by understanding causation from a dispositionalist stance, many (...) of the processes within an evidence-based practice framework are better accounted for. Further, some of the problems associated with the health research, e.g. external validity of causal findings, dissolve. (shrink)

In a recent reply to our article, “What is Interpretability?,” Prasetya argues against our position that artificial neural networks are explainable. It is claimed that our indefeasibility thesis—that adding complexity to an explanation of a phenomenon does not make the phenomenon any less explainable—is false. More precisely, Prasetya argues that unificationist explanations are defeasible to increasing complexity, and thus, we may not be able to provide such explanations of highly complex AI models. The reply highlights an important lacuna in our (...) original paper, the omission of the unificationist account of explanation, and affords us the opportunity to respond. Here, we argue that artificial neural networks are explainable in a way that should satisfy unificationists and that interpretability methods present ways in which ML theories can achieve unification. (shrink)

Dreaming in sleep must depend on the activity of the brain as does cognition and memory in wakefulness. Yet our understanding of the physiological subtleties of state differences may still be too primitive to guide theories adequately in these areas. One can state nonetheless unequivocally that the brain in REM is poorly equipped to practice for eventualities of wakefulness through dreaming, or for consolidating into memory the complex experiences of that state. [Hobson et al., Nielsen, Solms, Vertes & Eastman, Revonsuo].

Abductive reasoning is central to reconstructing the past in the geosciences. This paper outlines the nature of the abductive method and restates it in Bayesian terms. Evidence plays a key role in this working method and, in particular, traces of the past are important in this explanatory framework. Traces, whether singularly or as groups, are interpreted within the context of the event for which they have evidential claims. Traces are not considered as independent entities but rather as inter-related pieces of (...) information concerning the likelihood of specific events. Exemplification of the use of such traces is provided by dissecting an example of their use in the environmental reconstruction of mountain climate. (shrink)

There is growing evidence that dopamine replacement therapy (DRT) used to treat Parkinson’s Disease can cause compulsive behaviours and impulse control disorders (ICDs), such as pathological gambling, compulsive buying and hypersexuality. Like more familiar drug-based forms of addiction, these iatrogenic disorders can cause significant harm and distress for sufferers and their families. In some cases, people treated with DRT have lost their homes and businesses, or have been prosecuted for criminal sexual behaviours. In this article we first examine the evidence (...) that these disorders are caused by DRT. If it is accepted that DRT cause compulsive or addictive behaviours in a significant minority of individuals, then the following ethical and clinical questions arise: Under what circumstances is it ethical to prescribe a medication that may induce harmful compulsive behaviours? Are individuals treated with DRT morally responsible and hence culpable for harmful or criminal behaviour related to their medication? We conclude with some observations of the relevance of DRT-induced ICDs for our understanding of addiction and identify some promising directions for future research and ethical analysis. (shrink)

The proteasome family of proteases comprises oligomeric assemblies of very different symmetry. In different sizes, it features ring‐like oligomers with dihedral symmetry that allow the stacking of further rings of regulatory subunits as observed in the modular proteasome system, but also less symmetric helical assemblies. Comprehensive sequence and structural analyses of proteasome homologs reveal a parsimonious scenario of how symmetry may have emerged from a monomeric ancestral precursor and how it may have evolved throughout the proteasome family. The four characterized (...) representatives—ancestral β subunit (Anbu), HslV, betaproteobacterial proteasome homolog (BPH), and the 20S proteasome—are outlasting cornerstones in the family's evolutionary history, each marking a transition in symmetry. This article contextualizes the evolutionary and functional key aspects of these symmetry transitions, explaining how they facilitated the diversification and concurrent evolution of independent proteolytic systems side by side, each with its customized network of auxiliary interactors. -/- . (shrink)

Here we describe how more important findings were obtained in a delirium study by using an informal assessment of mental capacity, and, in those who lacked capacity, obtaining consent later when or if capacity returned or a proxy was found. From a total of 233 patients 23 patients lacked capacity as judged by our informal capacity judgment and 210 did not. Of those who lacked capacity, 13 agreed to enter in the study. Six of them regained capacity later. When these (...) 13 participants were excluded from analysis, significant findings were no longer evident. These results show that by the inclusion of subjects who lacked capacity the results of analyses of the condition from whish they suffer are altered. We suggest that this approach to the study of delirium is more ethical than the usual system of strict exclusion of people who lack capacity to give consent and for whom assent is not available. (shrink)

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

Résumé Cet article examine la manière dont Jean Scot Érigène s’approprie et emploie de façon constructive l’anthropologie de Maxime le Confesseur. Il s’agit de montrer que la division en cinq parties de l’être, puisée dans l’ Ambiguum 41 de Maxime le Confesseur, constitue le cadre du Periphyseon. Selon l’auteur, la compréhension de l’être humain de Maxime le Confesseur comme « un atelier de création », comme la synthèse de tous les aspects de la création, comme un agent d’unification, fournit la (...) prémisse anthropologique pour la division dialectique du genre de la nature propre à Érigène. C’est dans le cadre de l’ontologie de Maxime centrée sur « l’homme comme un atelier de création » qu’Érigène a recours à la tradition des arts libéraux. Par conséquent, la division du genre de la nature comme un exercice dialectique doit être comprise dans le cadre de l’appropriation par Érigène de la division en cinq parties de l’être de Maxime le Confesseur, ainsi que de son corollaire, l’anthropologie de l’ officina omnium o. Le projet du Periphyseon est guidé par la possibilité qu’à travers l’application des arts, l’homme pourrait devenir l’ officina omnium, en dépit de la chute ; si la connaissance intellectuelle de la création peut être achevée, alors le retour de toute la création à l’unité de l’être humain intelligible et ultimement à celle de Dieu pourrait être garanti. (shrink)

This article explores archival accounts of the experimental community, Kingsley Hall, established by R. D. Laing, the radical Scottish psychiatrist. The paper contributes to renewed interest in Kingsley Hall, R. D. Laing's radical psychiatry and UK counterculture. Archival sources enable not only the further exploration of already known figures but also let us hear previously unheard voices. Following a discussion of archival materials, the Hall is analyzed thematically and historically as an inner spaceship; an embattled middle-class countercultural plantation; a site (...) of spiritual renewal and development; a single-building arts colony; and a countercultural experiment. Finally, it is argued that with re-evaluation of 1960s and 1970s counterculture now underway on the Left, the Hall’s experiment in Laingian countercultural psychiatry—as we may fittingly call it—may yet inform future radical projects. (shrink)

This white paper outlines the plans of the History Philosophy Culture Working Group of the Next Generation Event Horizon Telescope Collaboration.

John Scottus Eriugena (d. ca. 877) is regarded as the most important philosopher and theologian in the Latin West from the death of Boethius until the thirteenth century. He incorporated his understanding of Latin sources, Ambrose, Augustine, Boethius and Greek sources, including the Cappadocian Fathers, Pseudo-Dionysius, and Maximus Confessor, into a metaphysics structured on Aristotle's Categories, from which he developed Christian Neoplatonist theology that continues to stimulate 21st-century theologians. This collection of essays provides an overview of the latest scholarship on (...) various aspects of Eriugena's thought and writings, including his Irish background, his use of Greek theologians, his Scripture hermeneutics, his understanding of Aristotelian logic, Christology, and the impact he had on contemporary and later theological traditions. Contributors: David Albertson, Joel Barstad, John Contreni, Christophe Erismann, John Gavin, Adrian Guiu, Michael Harrington, Catherine Kavanagh, A. Kijewska, Stephen Lahey, Elena Lloyd-Sidle, Bernard McGinn, Ernesto Sergio Mainoldi, Dermot Moran, Giulio D'Onofrio, Willemien Otten, and Alfred Siewers. (shrink)

Com podem fer per individuar accions? Com determinem quines accions són diferents d'unes altres? El present treball discutirà dues teories sobre la individuació d'accions: la de Davidson i la de Goldman. Atenent a un clàssic escenari filosòfic sobre la individuació d'accions veurem les virtuds i defectes d'aquestes dues propostes.

Contributing to renewed scholarly interest in R. D. Laing and his circle, and in the radical therapeutic community of Kingsley Hall, London, this article offers the first article-length reading of Mary Barnes’ and Joseph Berke’s Mary Barnes: Two Accounts of a Journey through Madness. This text offers views of anti-psychiatry ‘on the ground’ that critique the 1960s utopianism of Laing’s championing of madness as a metanoic, quasi-psychedelic voyage. Barnes’ story, too, reveals tensions within the anti-psychiatric movement. Moving beyond existing criticism (...) of the text, Barnes, it is argued here, emerges as far more than an exemplary patient, victim or anti-psychiatric puppet. Particular attention is paid in this reading of Two Accounts to the following: the ways in which the spiritually inclined Barnes and the psychoanalytic Berke differ in this dual narrative text; the ways in which each differs from Laing; the metaphor of the journey; and the setting of Barnes’ story in the often conflicted, experimental household of Kingsley Hall. (shrink)

Resenha de Chaisemartin, N.; Theodorescu, D. Le théâtre d’Aphrodisias : les structures scéniques. Aphrodisias 8.

The theorist who denies the objective reality of non-relational temporal properties, or ‘A-series’ determinations, must explain our experience of the passage of time. D.H. Mellor, a prominent denier of the objective reality of temporal passage, draws, in part, on Kant in offering a theory according to which the experience of temporal passage is the result of the projection of change in belief. But Mellor has missed some important points Kant has to make about time-awareness. It turns out that Kant's theory (...) of time-awareness also involves projection – but for him, the projection of temporal passage is necessary to any coherent experience at all, and for this reason events in the world cannot be represented except as exhibiting real tensed change. Consequently we cannot intelligibly suppose the world we know to be without the passage of time. This fact would permit a modest transcendental argument the conclusion of which is that we are entitled to describe the world in terms of temporal passage. (shrink)

Le manuscrit latin 13953 de la Bibliothèque Nationale de France contient aux ff. 25v-41v des gloses en latin et en vieux-haut-allemand portant sur laConsolatio Philosophiae de Boèce. Ces gloses sont transcrites dans leur intégralité ci-après, dans l'attente d'une édition critique complète du soi-disant 'commentaire anonyme de Saint-Gall. (IXᵉ-Xᵉ siècles), transmis dans différentes versions par une quinzaine de manuscrits. Dans l'étude qui précède l'édition, l'auteur analyse le manuscrit et le texte, et il formule des hypothèses sur son origine et sa nature. (...) L'auteur montre que la description de Pierre Courcelle ('Abrégé [de l'Anonyme de Saint-Gall]...') est erronée: le texte, qui constitue la transcription continue d'une glossica circumscriptio, est en fait une rédaction primitive du soi-disant commentaire anonyme de Saint-Gall, mais il contient aussi des gloses sans correspondance dans les versions ultérieures et plus étoffées de cette famille de commentaires. (shrink)

Le manuscrit latin 13953 de la Bibliothèque Nationale de France contient aux ff. 25v-41v des gloses en latin et en vieux-haut-allemand portant sur laConsolatio Philosophiae de Boèce. Ces gloses sont transcrites dans leur intégralité ci-après, dans l'attente d'une édition critique complète du soi-disant 'commentaire anonyme de Saint-Gall. (IXᵉ-Xᵉ siècles), transmis dans différentes versions par une quinzaine de manuscrits. Dans l'étude qui précède l'édition, l'auteur analyse le manuscrit et le texte, et il formule des hypothèses sur son origine et sa nature. (...) L'auteur montre que la description de Pierre Courcelle ('Abrégé [de l'Anonyme de Saint-Gall]...') est erronée: le texte, qui constitue la transcription continue d'une glossica circumscriptio, est en fait une rédaction primitive du soi-disant commentaire anonyme de Saint-Gall, mais il contient aussi des gloses sans correspondance dans les versions ultérieures et plus étoffées de cette famille de commentaires. (shrink)

Le présent travail se veut avant tout une introduction bibliographique à l'étude de la codicologie et de la paléographie latine en Roumanie. Les quelques 150 études et volumes qui y sont recensés et commentés donnent un tableau des directions d'étude prises par les chercheurs roumains dans ces domaines. Dansl'introduction, les auteurs proposent une évaluation de la recherche paléographique et codicologique roumaine du XXᵉ siècle, tout en suggérant de nouvelles voies à explorer. Dans ce sens, la priorité devrait être donnée à (...) un inventaire des manuscrits médiévaux en écriture latine conservés sur le territoire roumain, cequi débouchera sur la rédaction d'un catalogue général de ces manuscrits. Parallèlement, la recherche codicologique devrait produire des études détailléesdes reliures médiévales et modernes et des autres éléments structuraux du codex. La décoration des manuscrits, qui a déjà attiré l'attention des historiens d'artpar le passé, se doit d'être étudiée de nouveau dans une perspective codicologique et d'histoire du livre manuscrit. Enfin, un autre but est d'imposer un vocabulaire codicologique roumain, conforme aux progrès et innovations terminologiques de la recherche européenne contemporaine. (shrink)

This paper describes and discusses a new postgraduate course based on the dialogue-seminar method. The course and the method have been developed within the research area of skill and technology, based at the Royal Institute of Technology in Stockholm. The main features of the course were dialogue and reflection on practice of research inspired by reading of the source texts from the history of science and philosophy written by: Descartes, Leibniz, Diderot, D’Alembert, Gadamer, Galileo and Darwin. The concept of liberal (...) education was of importance in the design of the course. Doctoral students were all adults interested in applying of research in order to improve practices at their own work places. (shrink)